A Novel Idea for Coil Collar Structures in Accelerator Superconducting Magnets

The dipoles for several different machines (LHC, SSC, HERA) were designed using non-magnetic metallic collars to contain the superconducting coils. The coils are of two types, main and floating. This paper describes a structure with combined steel and plastic collars. Since the floating collars do not give an important contribution to the global rigidity of the dipole we propose to suppress them. The plastic collars are just fillers to limit the helium contained in the cold mass. Some data about thermoplastic materials to be possibly used for the collars are given and some estimations of mass and cost of this configuration are made. Finally the results of the tests of a 1-m-long twin aperture dipole with mixed steel-plastic collars are shortly described. The replacement of expensive alloys by high performance plastic in non-structural components can be a cost-effective solution in view of future projects where superconducting magnets are involved and contained costs are a key issue

Characteristics of the Austenitic Steels Used in the LHC Main Dipoles

The LHC dipole structure is assembled using austenitic steel collars and austenitic steel end-laminations. The collars will be fine-blanked starting from 11'000 tonnes of steel; the end-laminations require 1'700 tonnes of steel. The procurement of the austenitic steels was divided in two phases: first we qualified different grades from different producers then we made the call for tender, adjudicated the contract and started the series production. The first part of this paper summarises the results of the first qualification phase when extensive checks and measurements were carried out on five different grades. The second part describes the approach used to control the series production and the results obtained. At the time of writing about 19% of the steel for collars and end-laminations has been manufactured and delivered

Statistical Studies of the Robustness of the LHC Main Dipole Mechanical Structure

This paper describes two methods used to study the effect of the tolerances of the components on the structure of the LHC main dipole. The first method, called semi-statistical, is useful for the study of the effect of single different parameters and allows the determination of the acceptable variance of the dimensions of magnet components. The second one, fully statistical, allows the study of the combined effect of many parameters. The use of these two methods allowed to evaluate with good confidence the robustness of two different dipole cross-section designs, featuring austenitic and aluminium alloy collars, respectively

FEM Computations Concerning the Effect of Friction in Two LHC Main Dipole Structures

The mechanical behaviour of a dipole structure is considered when also friction is taken into account, studying its effect on different components and in different conditions. In particular the difference in behavior between a structure with aluminium collars and one with austenitic steel ones was studied

Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: Functional and therapeutic implications

This article is made available through the Brunel Open Access Publishing Fund. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.CLU (clusterin) is a tumor suppressor gene that we have previously shown to be negatively modulated by the MYCN proto-oncogene, but the mechanism of repression was unclear. Here, we show that MYCN inhibits the expression of CLU by direct interaction with the non-canonical E box sequence CACGCG in the 5′-flanking region. Binding of MYCN to the CLU gene induces bivalent epigenetic marks and recruitment of repressive proteins such as histone deacetylases and Polycomb members. MYCN physically binds in vitro and in vivo to EZH2, a component of the Polycomb repressive complex 2, required to repress CLU. Notably, EZH2 interacts with the Myc box domain 3, a segment of MYC known to be essential for its transforming effects. The expression of CLU can be restored in MYCN-amplified cells by epigenetic drugs with therapeutic results. Importantly, the anticancer effects of the drugs are ablated if CLU expression is blunted by RNA interference. Our study implies that MYC tumorigenesis can be effectively antagonized by epigenetic drugs that interfere with the recruitment of chromatin modifiers at repressive E boxes of tumor suppressor genes such as CLU.SPARKS, The Neuroblastoma Society, a Wellcome Trust grant (to A. S.), and the Italian Association for Cancer Research

Summary of the CMS Discovery Potential for the MSSM SUSY Higgses

This work summarises the present understanding of the expected MSSM SUSY Higgs reach for CMS. Many of the studies presented here result from detailed detector simulations incorporating final CMS detector design and response. With 30 fb-1 the h -> gamma,gamma and h -> bb channels allow to cover most of the MSSM parameter space. For the massive A,H,H+ MSSM Higgs states the channels A,H -> tau,tau and H+ -> tau,nu turn out to be the most profitable ones in terms of mass reach and parameter space coverage. Consequently CMS has made a big effort to trigger efficiently on taus. Provided neutralinos and sleptons are not too heavy, there is an interesting complementarity in the reaches for A,H -> tau,tau and A,H -> chi,chi.Comment: 19 pages, 27 figure

First Experience in the Mass Production of Components for the LHC Dipoles

This paper reports on the manufacturing features and difficulties experienced for the preliminary mass production of the main mechanical components of the dipole cold mass. The production of about 600 km of superconducting coil copper wedges, 5'000 coil layer jump spacers and boxes, 12'500'000 austenitic steel collars and 5'800'000 low-carbon yoke laminations is spread over 4 European countries and involves 6 manufactory firms. The general technical requirements for the manufacturing process as well as the imposed production checks and quality controls are reviewed. An overview of the preliminary results is presented with an outlook towards the analysis and statistical which are in a process to be implemented for the follow-up of the mass production

Design Features and Performance of a 10 T Twin Aperture Model Dipole for LHC

A twin-aperture superconducting (sc) dipole model has been designed in collaboration with Finnish and Swedish Institutions and built at CERN. The cable critical current was attained at a central field of 10.5 T at a temperature of 1.77 K after three training quenches only. This model has shown a very good quench performance as well as a robust mechanical behavior over several thermal cycles. This p aper will discuss the design, the innovations of the mechanical structure, and the results obtained during the intensive campaigns of tests